GLP – 1 (S)

Research Applications:

1 Dual Incretin Receptor Agonism: GIP and GLP-1

AOD-9604 was developed by modifying the C-terminal segment (176–191) of human growth hormone (hGH). This region is believed to be responsible for hGH’s fat-reducing effects. Studies show AOD-9604 can stimulate lipolysis (fat breakdown) and inhibit lipogenesis (fat formation) in vitro without exerting significant effects on blood sugar or insulin sensitivity [1].

Its selective activation of lipolytic pathways without impacting IGF-1 makes it an important compound for researchers studying energy balance and fat metabolism mechanisms [2]. These features allow AOD-9604 to be studied in models where hGH-related mitogenic or diabetogenic effects are undesirable.

2 Applications in Peptide and Protein Research

In peptide research, BAC Water is frequently employed to reconstitute lyophilized peptides prior to experimental assays [3]. The bacteriostatic property of benzyl alcohol allows repeated vial entry without significant risk of microbial contamination during the research period [3]. This is particularly advantageous for experiments requiring incremental sampling or extended timelines.

3 Role in Stability and Sample Integrity Studies

BAC Water’s benzyl alcohol component plays a key role in maintaining sterility, which can reduce the risk of peptide degradation caused by microbial enzymes [4]. Researchers often investigate how various diluents affect peptide stability, and BAC Water is a preferred control when evaluating antimicrobial preservation effects [4].

4 Chemical Composition and Classification

BAC Water’s benzyl alcohol component plays a key role in maintaining sterility, which can reduce the risk of peptide degradation caused by microbial enzymes [4]. Researchers often investigate how various diluents affect peptide stability, and BAC Water is a preferred control when evaluating antimicrobial preservation effects [4].

1 Microbiology and Antimicrobial Research

While BAC Water’s bacteriostatic nature offers distinct research benefits, certain cell culture applications avoid benzyl alcohol due to its potential cytotoxicity at higher concentrations [6]. PubChem data also notes that benzyl alcohol can disrupt certain enzymatic reactions in vitro [6]. Consequently, researchers carefully match the diluent to the specific assay requirements

Referenced Citations:

PubChem. “Bacteriostatic Water for Injection.” PubChem Compound Summary.

https://pubchem.ncbi.nlm.nih.gov/compound/Bacteriostatic-Water-for-Injection

PubChem. “Bacteriostatic Water for Injection.” PubChem Compound Summary.

https://pubchem.ncbi.nlm.nih.gov/compound/Bacteriostatic-Water-for-Injection

PubChem. “Bacteriostatic Water for Injection.” PubChem Compound Summary.

https://pubchem.ncbi.nlm.nih.gov/compound/Bacteriostatic-Water-for-Injection